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Krt14tm1Der
Targeted Allele Detail
Nomenclature
Symbol: Krt14tm1Der
Name: keratin 14; targeted mutation 1, Dennis R Roop
MGI ID: MGI:2653126
Synonyms: mtK14neo, mutneo
Gene: Krt14  Location: Chr11:100203162-100207510 bp, - strand  Genetic Position: Chr11, 63.43 cM, cytoband D
Severe blisters on the front legs, paws, and chest of Krt14tm1Der/Krt14tm1Der pups

Show the 1 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:67320
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129X1/SvJ
Mutation
description
Allele Type:    Targeted (Not Specified)
Mutations:    Insertion, Single point mutation
 
Mutation detailsA C to T point mutation at codon 131 was introduced to the gene and a floxed PGK-neo cassette was inserted into the downstream exon via homologous recombination. The point mutation results in an arginine to cysteine substitution. The targeted allele was confirmed by Southern blot and sequence analysis. (J:67320)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Krt14 Mutation:  6 strains or lines available
References
Original:  J:67320 Cao T, et al., An Inducible Mouse Model for Epidermolysis Bullosa Simplex. Implications for gene therapy. J Cell Biol. 2001 Feb 5;152(3):651-6
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
08/06/2019
MGI 6.14
The Jackson Laboratory