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Targeted Allele Detail
Symbol: Ndntm1Mus
Name: necdin; targeted mutation 1, Francoise Muscatelli
MGI ID: MGI:2653059
Gene: Ndn  Location: Chr7:62346569-62350262 bp, + strand  Genetic Position: Chr7, 34.36 cM, cytoband C
Germline Transmission:  Earliest citation of germline transmission: J:66557
Parent Cell Line:  CK35 (ES Cell)
Strain of Origin:  129S2/SvPas
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsThe 5' two-thirds of the endogenous coding region was replaced with a floxed neo cassette inserted by homologous recombination. Normal transcript was undetected by Northern blot and RT-PCR analyses of both homozygous mutant mice and heterozygous mice carrying a paternal mutant allele. An absence of protein was verified in these mice by Western blot analysis of brain tissue. (J:66557)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ndn Mutation:  12 strains or lines available
Original:  J:66557 Muscatelli F, et al., Disruption of the mouse necdin gene results in hypothalamic and behavioral alterations reminiscent of the human prader-willi syndrome. Hum Mol Genet. 2000 Dec 12;9(20):3101-10
All:  2 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
The Jackson Laboratory