Lilrb4a^tm1Hrk
Targeted Allele Detail

Summary

• Symbol: Lilrb4a^tm1Hrk
• Name: leukocyte immunoglobulin-like receptor, subfamily B, member 4A; targeted mutation 1, Howard R Katz
• MGI ID: MGI:2653049
• Synonyms: gp49B^-
• Gene: Lilrb4a Location: Chr10:51367052-51372707 bp, + strand Genetic Position: Chr10, 25.5 cM, cytoband B4
• Alliance: Lilrb4a^tm1Hrk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:70491
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A region spanning intron 2 and most of exon 3 (which encodes the NH₂-terminal Ig-like domain) was replaced with a neomycin resistance cassette via homologous recombination. Absence of gene expression in homozygous mutant animals was confirmed by flow cytometric analysis. (J:70491)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lilrb4a Mutation: 28 strains or lines available

References

• Original: J:70491 Daheshia M, et al., Increased severity of local and systemic anaphylactic reactions in gp49B1-deficient mice. J Exp Med. 2001 Jul 16;194(2):227-34
• All: 8 reference(s)