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Targeted Allele Detail
Symbol: Ndntm1Stw
Name: necdin, MAGE family member; targeted mutation 1, Colin L Stewart
MGI ID: MGI:2653045
Gene: Ndn  Location: Chr7:62348277-62349928 bp, + strand  Genetic Position: Chr7, 34.36 cM, cytoband C
Germline Transmission:  Earliest citation of germline transmission: J:57890
Parent Cell Line:  W9.5/W95 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
Mutation detailsThe majority of the protein coding region of endogenous allele was replaced with a cassette containing lacZ and floxed neo. 31 5' codons were left intact. The expression pattern of lacZ differed from the expression pattern observed for Ndntm2Stw, which lacked the floxed neo sequence. (J:57890)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Mice Carrying this Mutation: 15 assay results
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ndn Mutation:  4 strains or lines available
Original:  J:57890 Gerard M, et al., Disruption of the mouse necdin gene results in early post-natal lethality [see comments]. Nat Genet. 1999 Oct;23(2):199-202
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.16
The Jackson Laboratory