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Targeted Allele Detail
Symbol: Kcnh2tm1Hjd
Name: potassium voltage-gated channel, subfamily H (eag-related), member 2; targeted mutation 1, Henry J Duff
MGI ID: MGI:2652959
Synonyms: ERG1 B-
Gene: Kcnh2  Location: Chr5:24319589-24351604 bp, - strand  Genetic Position: Chr5, 10.94 cM
Germline Transmission:  Earliest citation of germline transmission: J:82249
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsAn isoform specific mutation was generated by replacing the coding region of exon 1B with a floxed neomycin selection cassette. RT-PCR analysis verified that sequence upstream of the insertion, encoding the A isoform, was transcribed. Transcript encoding the B isoform was undected in homozygous mutant mice by RT-PCR analysis. (J:82249)
View phenotypes for all genotypes (concatenated display).
Disease models
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Kcnh2 Mutation:  3 strains or lines available
Original:  J:82249 Lees-Miller JP, et al., Selective knockout of mouse ERG1 B potassium channel eliminates I(Kr) in adult ventricular myocytes and elicits episodes of abrupt sinus bradycardia. Mol Cell Biol. 2003 Mar;23(6):1856-62
All:  1 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.0
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