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Hbb-ytm1Fier
Targeted Allele Detail
Nomenclature
Symbol: Hbb-ytm1Fier
Name: hemoglobin Y, beta-like embryonic chain; targeted mutation 1, Steven Fiering
MGI ID: MGI:2652936
Synonyms: deltaEy
Gene: Hbb-y  Location: Chr7:103851745-103853240 bp, - strand  Genetic Position: Chr7, 54.85 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:82296
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe gene was disrupted by replacement of exon 1 and exon 2 with a floxed PGK-hygro cassette via homologous recombination. The targeted mutation results in deletion of a 1.1 kb of DNA including the promoter region. Absence of gene expression in homozygous mutant animals was confirmed by RT-PCR analysis of embryonic yolk sac RNA. (J:82296)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hbb-y Mutation:  1 strain or line available
References
Original:  J:82296 Hu X, et al., Promoters of the murine embryonic beta-like globin genes Ey and betah1 do not compete for interaction with the beta-globin locus control region. Proc Natl Acad Sci U S A. 2003 Feb 4;100(3):1111-5
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/12/2016
MGI 6.04
The Jackson Laboratory