About   Help   FAQ
Targeted Allele Detail
Symbol: Hbb-bh1tm1Fier
Name: hemoglobin Z, beta-like embryonic chain; targeted mutation 1, Steven Fiering
MGI ID: MGI:2652935
Synonyms: deltabetah1
Gene: Hbb-bh1  Location: Chr7:103841637-103843164 bp, - strand  Genetic Position: Chr7, 54.85 cM
Germline Transmission:  Earliest citation of germline transmission: J:82296
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsThe gene was disrupted by replacement of exon 1 and exon 2 with a floxed PGK-neo cassette via homologous recombination. The targeted mutation results in deletion of a 1.1 kb of DNA including the promoter region. Absence of gene expression in homozygous mutant animals was confirmed by RT-PCR analysis of embryonic yolk sac RNA. (J:82296)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hbb-bh1 Mutation:  3 strains or lines available
Original:  J:82296 Hu X, et al., Promoters of the murine embryonic beta-like globin genes Ey and betah1 do not compete for interaction with the beta-globin locus control region. Proc Natl Acad Sci U S A. 2003 Feb 4;100(3):1111-5
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
MGI 6.11
The Jackson Laboratory