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Ikbkbtm2Cgn
Targeted Allele Detail
Nomenclature
Symbol: Ikbkbtm2Cgn
Name: inhibitor of kappaB kinase beta; targeted mutation 2, University of Cologne
MGI ID: MGI:2652651
Synonyms: Ikbkbtm1Mpa, Ikk2FL, IKK2flox
Gene: Ikbkb  Location: Chr8:22659212-22706589 bp, - strand  Genetic Position: Chr8, 11.42 cM, cytoband A3-A4
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:77233
Parent Cell Line:  Bruce 4 (ES Cell)
Strain of Origin:  B6.Cg-Thy1a
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA 2 kb fragment containing exons 6 and 7 was left flanked by single loxP sites after homologous recombination of a targeting vector and subsequent cre-mediated excision of the selection cassette prior to the production of chimeric mice. (J:77233)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ikbkb Mutation:  9 strains or lines available
References
Original:  J:77233 Pasparakis M, et al., TNF-mediated inflammatory skin disease in mice with epidermis-specific deletion of IKK2. Nature. 2002 Jun 20;417(6891):861-6
All:  34 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/11/2020
MGI 6.14
The Jackson Laboratory