Tg(Prnp)d11Cwe
Transgene Detail

Summary

• Symbol: Tg(Prnp)d11Cwe
• Name: transgene insertion d11, Charles Weissmann
• MGI ID: MGI:2652550
• Synonyms: pPrPdeltaN-term, PrPdelta32-80, tgd11
• Transgene: Tg(Prnp)d11Cwe Location: unknown
• Alliance: Tg(Prnp)d11Cwe page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Prnp)d11Cwe expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Prnp (MGI:97769)

• Mutation details: To define the requirements of Prnp for conferring susceptibility to scrapie, N- terminal deletion mutants of the Prnp genes were constructed in transgenic mice. In this transgenic line, amino acids 32-80 were deleted but the codons for signal sequence and nine additional amino acids were retained to ensure correct processing and cellular localization. (J:32214)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

Notes

Two founder lines were generated, D11 and D12.

References

• Original: J:32214 Fischer M, et al., Prion protein (PrP) with amino-proximal deletions restoring susceptibility of PrP knockout mice to scrapie. EMBO J. 1996 Mar 15;15(6):1255-64
• All: 3 reference(s)