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Targeted Allele Detail
Symbol: Zfp36tm1Pjb
Name: zinc finger protein 36; targeted mutation 1, Perry J Blackshear
MGI ID: MGI:2652418
Synonyms: TTP-, TTP(-)
Gene: Zfp36  Location: Chr7:28376784-28379228 bp, - strand  Genetic Position: Chr7, 16.72 cM
Germline Transmission:  Earliest citation of germline transmission: J:33986
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
Mutation detailsExon 2 was disrupted by the insertion of a neomycin selection cassette. Multiple stop codons were generated upstream of sequence encoding two putative zinc fingers. Northern blot analysis showed an absence of normal transcript and identified an aberrant transcript containing neo. Neither normal nor truncated protein was detected by Western blot analysis of MEFs derived from homozygous mutant mice. (J:33986)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Structures Affected by this Mutation: 17 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Zfp36 Mutation:  12 strains or lines available
Original:  J:33986 Taylor GA, et al., A pathogenetic role for TNF alpha in the syndrome of cachexia, arthritis, and autoimmunity resulting from tristetraprolin (TTP) deficiency. Immunity. 1996 May;4(5):445-54
All:  40 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory