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Targeted Allele Detail
Symbol: Tsta3tm1Jbl
Name: tissue specific transplantation antigen P35B; targeted mutation 1, John Lowe
MGI ID: MGI:2651890
Synonyms: FX(-), Tstap35btm1Umich
Gene: Tsta3  Location: Chr15:75924684-75929730 bp, - strand  Genetic Position: Chr15, 35.1 cM
Colon of Tsta3tm1Jbl/Tsta3tm1Jbl mice exhibits characteristics of inflammatory bowel disease that is reversed with fucose supplementation

Show the 1 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:82239
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsExons 4 through 6 were replaced by a neomycin selection cassette inserted by homologous recombination. (J:82239)
View phenotypes for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tsta3 Mutation:  15 strains or lines available
Original:  J:82239 Smith PL, et al., Conditional control of selectin ligand expression and global fucosylation events in mice with a targeted mutation at the FX locus. J Cell Biol. 2002 Aug 19;158(4):801-15
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.06
The Jackson Laboratory