Egr2^tm1.1Jchn
Targeted Allele Detail

Summary

• Symbol: Egr2^tm1.1Jchn
• Name: early growth response 2; targeted mutation 1.1, James Cohen
• MGI ID: MGI:2651550
• Synonyms: Krox20^DT
• Gene: Egr2 Location: Chr10:67371305-67378018 bp, + strand Genetic Position: Chr10, 34.96 cM, cytoband B5
• Alliance: Egr2^tm1.1Jchn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:82071
• Parent Cell Line: CK35 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Inserted expressed sequence)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Cre-mediated excision of the floxed EGFP sequence from Egr2^tm1Jchn enabled expression of sequence encoding the dipterhia toxin A subunit (DT) which had replaced the endogenous 5' coding region. Expression of DT putatively results in the elimination of boundary cap cells around E11.5. (J:82071)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Egr2 Mutation: 31 strains or lines available

References

• Original: J:82071 Vermeren M, et al., Integrity of developing spinal motor columns is regulated by neural crest derivatives at motor exit points. Neuron. 2003 Feb 6;37(3):403-15
• All: 1 reference(s)