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Neurog3tm1(EGFP)Khk
Targeted Allele Detail
Nomenclature
Symbol: Neurog3tm1(EGFP)Khk
Name: neurogenin 3; targeted mutation 1, Klaus H Kaestner
MGI ID: MGI:2651394
Synonyms: Neurog3EGFP, ngn3-, Ngn3-eGFP
Gene: Neurog3  Location: Chr10:62133090-62134763 bp, + strand  Genetic Position: Chr10, 32.35 cM, cytoband B4
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:77398
Parent Cell Line:  TL1/TL-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA PGK-neomycin resistance cassette containing EGFP cDNA and lox sites flanking the PGK-neo sequence replaced the coding region. Confocal images detected EGFP expression in the glandular stomach of P3 heterozygous mutant mice, and not in the squamous epithelium of the forestomach. (J:77398)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 5 assay results
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Neurog3 Mutation:  15 strains or lines available
References
Original:  J:77398 Lee CS, et al., Neurogenin 3 is essential for the proper specification of gastric enteroendocrine cells and the maintenance of gastric epithelial cell identity. Genes Dev. 2002 Jun 15;16(12):1488-97
All:  28 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/22/2020
MGI 6.16
The Jackson Laboratory