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Targeted Allele Detail
Symbol: Fancltm1Ceb
Name: Fanconi anemia, complementation group L; targeted mutation 1, Colin E Bishop
MGI ID: MGI:2451263
Synonyms: Pog-
Gene: Fancl  Location: Chr11:26387084-26471883 bp, + strand  Genetic Position: Chr11, 15.85 cM, cytoband A2-A3
Germline Transmission:  Earliest citation of germline transmission: J:80424
Parent Cell Line:  AB1 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprt+
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsThe endogenous allele was disrupted by the insertion of a vector containing exons 9 through 13, selection genes, and a 300 bp gap in intron 11. Homologous recombination of the vector results in double stranded gap repair, producing an allele in which exon 13 is followed by the selection genes and duplicates of exons 9 through 13. Transcript was undetected in homozygous mutant mice by RT-PCR analysis of gonad and spleen tissue. Expression of Vrk2, the adjacent locus, was unaffected. (J:80424)
View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 4 assay results
In Structures Affected by this Mutation: 7 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Fancl Mutation:  5 strains or lines available
Original:  J:80424 Agoulnik AI, et al., A novel gene, Pog, is necessary for primordial germ cell proliferation in the mouse and underlies the germ cell deficient mutation, gcd. Hum Mol Genet. 2002 Nov 15;11(24):3047-53
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.15
The Jackson Laboratory