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Targeted Allele Detail
Symbol: Hba-a1tm1Shs
Name: hemoglobin alpha, adult chain 1; targeted mutation 1, Takuji Shirasawa
MGI ID: MGI:2451238
Synonyms: alphaTitu
Gene: Hba-a1  Location: Chr11:32283511-32284465 bp, + strand  Genetic Position: Chr11, 18.86 cM
Germline Transmission:  Earliest citation of germline transmission: J:81902
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Allele Type:    Targeted
Mutations:    Insertion, Single point mutation
Mutation detailsA transition point mutation was introduced at codon 94 via site directed mutagenesis, resulting in an Asp to Asn substitution at the alpha/beta interface of the hemoglobin molecule. An intronic floxed neo cassette was included downstream of the coding region. (J:81902)
View phenotypes for all genotypes (concatenated display).
Disease models
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hba-a1 Mutation:  1 strain or line available
Original:  J:81902 Shirasawa T, et al., Oxygen affinity of hemoglobin regulates O2 consumption, metabolism, and physical activity. J Biol Chem. 2003 Feb 14;278(7):5035-43
All:  1 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 5.21
The Jackson Laboratory