About   Help   FAQ
Targeted Allele Detail
Symbol: Mtm1tm1.1Jman
Name: X-linked myotubular myopathy gene 1; targeted mutation 1.1, Jean-Louis Mandel
MGI ID: MGI:2450997
Synonyms: MTM1delta4
Gene: Mtm1  Location: ChrX:71215006-71315691 bp, + strand  Genetic Position: ChrX, 36.55 cM
Clinical evaluation of muscle weakness in Mtm1tm1.1Jman/Y mice

Show the 3 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:81791
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129T1/Sv-Dnd1Ter
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
Mutation detailsThis allele is created by mating Mtm1tm1Jman mice to a CMV-cre deleter strain. Cre-mediated recombination results in deletion of the neo cassette and exon 4 contained within flanking loxP sites. Absence of gene expression in homozygous mutant animals was confirmed by Western blot analysis. (J:81791)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Mtm1 Mutation:  23 strains or lines available
Original:  J:81791 Buj-Bello A, et al., The lipid phosphatase myotubularin is essential for skeletal muscle maintenance but not for myogenesis in mice. Proc Natl Acad Sci U S A. 2002 Nov 12;99(23):15060-5
All:  14 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
MGI 6.11
The Jackson Laboratory