About   Help   FAQ
Six3tm1Gco
Targeted Allele Detail
Nomenclature
Symbol: Six3tm1Gco
Name: sine oculis-related homeobox 3; targeted mutation 1, Guillermo Oliver
MGI ID: MGI:2450901
Synonyms: Six3-
Gene: Six3  Location: Chr17:85613608-85630791 bp, + strand  Genetic Position: Chr17, 55.42 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:81797
Parent Cell Line:  W9.5/W95 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutation:    Insertion
 
Mutation detailsThe endogenous allele was disrupted by the in frame insertion of Beta-gal and neo 22 codons downstream of the start codon. An absence of protein in homozygous mutant mice was indicated by immunofluorescence. (J:81797)
Phenotypes
Loading...
View phenotypes for all genotypes (concatenated display).
Disease models
Loading...
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Six3 Mutation:  0 strains or lines available
References
Original:  J:81797 Lagutin OV, et al., Six3 repression of Wnt signaling in the anterior neuroectoderm is essential for vertebrate forebrain development. Genes Dev. 2003 Feb 1;17(3):368-79
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
04/21/2015
MGI 5.21
The Jackson Laboratory