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Targeted Allele Detail
Symbol: Il17ratm1Koll
Name: interleukin 17 receptor A; targeted mutation 1, Jay K Kolls
MGI ID: MGI:2450882
Synonyms: IL-17R-, IL-17R KO
Gene: Il17ra  Location: Chr6:120463247-120487559 bp, + strand  Genetic Position: Chr6, 56.95 cM
Germline Transmission:  Earliest citation of germline transmission: J:71097
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA 5.7 kb genomic fragment encompassing exons 4 through 11 was replaced with a PGK-neo cassette inserted by homologous recombination. The deleted region corresponds with nt 445 through 1172 of the cDNA. Absence of the normal protein in homozygous mutant mice was indicated by flow cytometric analysis of spleen and peritoneal exudate cells. (J:71097)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Il17ra Mutation:  16 strains or lines available
Original:  J:71097 Ye P, et al., Requirement of interleukin 17 receptor signaling for lung CXC chemokine and granulocyte colony-stimulating factor expression, neutrophil recruitment, and host defense. J Exp Med. 2001 Aug 20;194(4):519-27
All:  118 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
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