Gca^tm1Roes
Targeted Allele Detail

Summary

• Symbol: Gca^tm1Roes
• Name: grancalcin; targeted mutation 1, Jurgen Roes
• MGI ID: MGI:2450787
• Synonyms: Gca 1/1
• Gene: Gca Location: Chr2:62494671-62524453 bp, + strand Genetic Position: Chr2, 36.47 cM
• Alliance: Gca^tm1Roes page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:81436
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A floxed neomycin gene cassette was inserted into exon 4, disrupting the region encoding the second EF hand domain. (J:81436)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Gca Mutation: 16 strains or lines available

References

• Original: J:81436 Roes J, et al., Granulocyte function in grancalcin-deficient mice. Mol Cell Biol. 2003 Feb;23(3):826-30
• All: 3 reference(s)