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Targeted Allele Detail
Symbol: Htr7tm1Sut
Name: 5-hydroxytryptamine (serotonin) receptor 7; targeted mutation 1, J Gregor Sutcliffe
MGI ID: MGI:2450732
Synonyms: 5-HT7-
Gene: Htr7  Location: Chr19:35958734-36057507 bp, - strand  Genetic Position: Chr19, 30.3 cM
Germline Transmission:  Earliest citation of germline transmission: J:81842
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129/Sv
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
Mutation detailsThe gene was disrupted by insertion of a neomycin resistance gene into exon 2 via homologous recombination. Northern blot analysis detected mutant transcripts in homozygous mutant animals. It is believed that no functional product is encoded by the mutant transcript due to multiple stop codons within the sequence. (J:81842)
View phenotypes for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Htr7 Mutation:  11 strains or lines available
Original:  J:81842 Hedlund PB, et al., No hypothermic response to serotonin in 5-HT7 receptor knockout mice. Proc Natl Acad Sci U S A. 2003 Feb 4;100(3):1375-80
All:  10 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.06
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