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Ros1tm2Cbm
Targeted Allele Detail
Nomenclature
Symbol: Ros1tm2Cbm
Name: Ros1 proto-oncogene; targeted mutation 2, Carmen Birchmeier
MGI ID: MGI:2450662
Synonyms: c-ros-, roskin
Gene: Ros1  Location: Chr10:52045721-52195244 bp, - strand  Genetic Position: Chr10, 26.18 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:33259
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin resistance cassette replaced two exons that encode the protein kinase domain. This region corresponds to nucleotides 6267-6467 of the cDNA. Western blot analysis using antibodies against a carboxy-terminal peptide did not detect protein in epididymal extracts from homozygous mutant mice. (J:33259)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ros1 Mutation:  59 strains or lines available
References
Original:  J:33259 Sonnenberg-Riethmacher E, et al., The c-ros tyrosine kinase receptor controls regionalization and differentiation of epithelial cells in the epididymis. Genes Dev. 1996 May 15;10(10):1184-93
All:  7 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/23/2016
MGI 6.05
The Jackson Laboratory