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Tg(Plp1-cre/ERT)3Pop
Transgene Detail
Nomenclature
Symbol: Tg(Plp1-cre/ERT)3Pop
Name: transgene insertion 3, Brian Popko
MGI ID: MGI:2450391
Synonyms: PLP/CreER, Plp-CreERt, Plp-Cre-ERT2, Tg(Plp1-cre/ESR1)3.16Pop, Tg(Plp1-cre/ESR1)3Pop, Tg(Plp-cre/ESR1)3.16Pop
Transgene: Tg(Plp1-cre/ERT)3Pop  Location: unknown  
Transgene
origin
Strain of Origin:  (C57BL/6 x DBA/2)F1
Transgene
description
Transgene Type:    Transgenic (Inducible, Recombinase)
Inducer:    tamoxifen
Mutation:    Insertion
 
Mutation detailsThe transgenic construct encodes a tamoxifen inducible fusion protein consisting of cre recombinase and a mutated human estrogen receptor ligand binding domain cloned next to a Plp promoter. The 2.5 kb Plp regulatory region includes 5' flanking DNA, exon 1, and intron 1. Transgene expression was confirmed by RT-PCR and Western blot analysis. The mouse Plp promoter was used to drive transgene expression in myelinating cells. (J:81627)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Plp1     Summary of all recombinase alleles driven by Plp1.
 

Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
References
Original:  J:81627 Doerflinger NH, et al., Inducible site-specific recombination in myelinating cells. Genesis. 2003 Jan;35(1):63-72
All:  87 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/05/2019
MGI 6.14
The Jackson Laboratory