About   Help   FAQ
Tg(Tek-cre/ERT2)1Arnd
Transgene Detail
Nomenclature
Symbol: Tg(Tek-cre/ERT2)1Arnd
Name: transgene insertion 1, Bernd Arnold
MGI ID: MGI:2450312
Synonyms: L43Tie2CreT2, Tg(Tek-cre/ESR1)1Arnd, Tie2-CreERT2, Tie2ERT2Cre
Transgene: Tg(Tek-cre/ERT2)1Arnd  Location: unknown  
Transgene
origin
Strain of Origin:  (C57BL/6 x DBA/2)
Transgene
description
Transgene Type:    Transgenic (Inducible, Recombinase)
Inducer:    tamoxifen
Mutation:    Insertion
 
Mutation detailsThe transgenic construct encodes a tamoxifen inducible fusion protein consisting of cre recombinase and a mutated human estrogen receptor ligand binding domain fused to the mouse Tek promoter and 10.5 kb of the first intron. Transgene expression in endothelial cells of the liver and kidney was confirmed by immunohistochemical analysis. (J:81649)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Tek     Summary of all recombinase alleles driven by Tek. Comparative matrix view of recombinase activities
 

Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Notes
Two transgenic lines displaying endothelial-specific transgene expression, designated L34 and L43, were created.
References
Original:  J:81649 Forde A, et al., Temporal Cre-mediated recombination exclusively in endothelial cells using Tie2 regulatory elements. Genesis. 2002 Aug;33(4):191-7
All:  26 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
09/10/2019
MGI 6.14
The Jackson Laboratory