Foxk1^tm1Djg
Targeted Allele Detail

Summary

• Symbol: Foxk1^tm1Djg
• Name: forkhead box K1; targeted mutation 1, Daniel J Garry
• MGI ID: MGI:2450307
• Synonyms: Foxk1^-, Mnf^-
• Gene: Foxk1 Location: Chr5:142387252-142447766 bp, + strand Genetic Position: Chr5, 81.53 cM
• Alliance: Foxk1^tm1Djg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:62225
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Sequence encoding the winged helix domain was replaced with a neomycin selection cassette by homologous recombination. The targeted sequence is common to both alpha- and beta- isoforms. RT-PCR analysis of homozygous mutant mice indicated an absence of transcript. Protein was undetected by immunohistochemical analysis. (J:62225)

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Foxk1 Mutation: 28 strains or lines available

References

• Original: J:62225 Garry DJ, et al., Myogenic stem cell function is impaired in mice lacking the forkhead/winged helix protein MNF. Proc Natl Acad Sci U S A. 2000 May 9;97(10):5416-21
• All: 2 reference(s)