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Targeted Allele Detail
Symbol: Foxk1tm1Djg
Name: forkhead box K1; targeted mutation 1, Daniel J Garry
MGI ID: MGI:2450307
Synonyms: Foxk1-, Mnf-
Gene: Foxk1  Location: Chr5:142401497-142462011 bp, + strand  Genetic Position: Chr5, 81.53 cM
Germline Transmission:  Earliest citation of germline transmission: J:62225
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsSequence encoding the winged helix domain was replaced with a neomycin selection cassette by homologous recombination. The targeted sequence is common to both alpha- and beta- isoforms. RT-PCR analysis of homozygous mutant mice indicated an absence of transcript. Protein was undetected by immunohistochemical analysis. (J:62225)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Foxk1 Mutation:  19 strains or lines available
Original:  J:62225 Garry DJ, et al., Myogenic stem cell function is impaired in mice lacking the forkhead/winged helix protein MNF. Proc Natl Acad Sci U S A. 2000 May 9;97(10):5416-21
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
The Jackson Laboratory