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Prxtm1Brp
Targeted Allele Detail
Nomenclature
Symbol: Prxtm1Brp
Name: periaxin; targeted mutation 1, Peter Brophy
MGI ID: MGI:2450150
Synonyms: Prx-
Gene: Prx  Location: Chr7:27499305-27520041 bp, + strand  Genetic Position: Chr7, 15.91 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:62566
Parent Cell Line:  CGR8 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA fragment extending from within exon 6 through a portion of exon 7 (corresponding to cDNA nt 611 through 3440) was replaced with a neomycin selection cassette inserted by homologous recombination. An absence L and S isoforms was verifed on both mRNA and protein levels by Northern and Western blot analyses of sciatic nerves. (J:62566)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Prx Mutation:  40 strains or lines available
References
Original:  J:62566 Gillespie CS, et al., Peripheral demyelination and neuropathic pain behavior in periaxin-deficient mice. Neuron. 2000 May;26(2):523-31
All:  9 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
12/03/2019
MGI 6.14
The Jackson Laboratory