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Commd10Tg(Vav1-icre)A2Kio
Transgenic Allele Detail
Nomenclature
Symbol: Commd10Tg(Vav1-icre)A2Kio
Name: COMM domain containing 10; transgene insertion A2, Dimitris Kioussis
MGI ID: MGI:2449949
Synonyms: Tg(Vav1-cre)1Kio, Tg(Vav1-cre)A2Kio, Tg(Vav1-icre)A2Kio, Vav1-Cre, Vav1 (HS21/5)-iCre, Vav-cre, VavCre, VavCredeBoer, Vav-iCre
Gene: Commd10  Location: Chr18:46958862-47087992 bp, + strand  Genetic Position: Chr18, 24.9 cM
Transgene
origin
Strain of Origin:  (CBA/Ca x C57BL/10)F2
Transgene
description
Transgene Type:    Transgenic (Null/knockout, Recombinase)
Mutation:    Insertion
 
Mutation detailsThis transgene expresses Cre recombinase under the control of a vav promoter. This promoter was shown to be active in lymph nodes, thymus, spleen, Peyer's patches, intestinal cryptopatches, ovaries and testes. Line A2 inserted into the gene at 47022629-47022630 (Build GRCm38/mm10). The insetion results in a functional knock-out in homozygous mice. (J:81568, J:253473)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Vav1     Summary of all recombinase alleles driven by Vav1.
 

Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Mice Carrying this Mutation: 3 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Commd10 Mutation:  20 strains or lines available
References
Original:  J:81568 De Boer J, et al., Transgenic mice with hematopoietic and lymphoid specific expression of Cre. Eur J Immunol. 2003 Feb;33(2):314-25
All:  227 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/15/2018
MGI 6.12
The Jackson Laboratory