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Fevtm1Esd
Targeted Allele Detail
Nomenclature
Symbol: Fevtm1Esd
Name: FEV (ETS oncogene family); targeted mutation 1, Evan S Deneris
MGI ID: MGI:2449922
Synonyms: Pet-1-, Pet1-, Pet-1 KO
Gene: Fev  Location: Chr1:74881509-74885419 bp, - strand  Genetic Position: Chr1, 38.54 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:81450
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe entire coding region was replaced with a neomycin selection cassette inserted by homologous recombination. Transcript was undetected by in situ hybridization of hindbrain tissue obtained from homozygous mutant mice. (J:81450)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Fev Mutation:  7 strains or lines available
References
Original:  J:81450 Hendricks TJ, et al., Pet-1 ETS Gene Plays a Critical Role in 5-HT Neuron Development and Is Required for Normal Anxiety-like and Aggressive Behavior. Neuron. 2003 Jan 23;37(2):233-47
All:  26 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
12/05/2017
MGI 6.11
The Jackson Laboratory