Lrp2^tm1Tew
Targeted Allele Detail

Summary

• Symbol: Lrp2^tm1Tew
• Name: low density lipoprotein receptor-related protein 2; targeted mutation 1, Thomas E Willnow
• MGI ID: MGI:2449765
• Synonyms: megalin^lox
• Gene: Lrp2 Location: Chr2:69254679-69416373 bp, - strand Genetic Position: Chr2, 40.74 cM
• Alliance: Lrp2^tm1Tew page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:81496
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: 3 exons were flanked by a 5' floxed neo cassette and a 3' single loxP site. The most 3' exon in the floxed region encodes the membrane anchor of the receptor. Western blot analysis of kidney tissue obtained from homozygous mutant mice indicated that a protein product was produced by the floxed allele. (J:81496)

Disease models

Expression

In Structures Affected by this Mutation:

15 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lrp2 Mutation: 260 strains or lines available

References

• Original: J:81496 Leheste JR, et al., Hypocalcemia and osteopathy in mice with kidney-specific megalin gene defect. FASEB J. 2003 Feb;17(2):247-9
• All: 34 reference(s)