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Targeted Allele Detail
Symbol: Anxa1tm1Rjf
Name: annexin A1; targeted mutation 1, Roderick J Flower
MGI ID: MGI:2449710
Synonyms: annexin 1-, Anx-1-, AnxA1(-), ANXA1 KO
Gene: Anxa1  Location: Chr19:20373434-20390671 bp, - strand  Genetic Position: Chr19, 13.83 cM
Anxa1tm1Rjf/Anxa1tm1Rjf mice exhibit a delay in colonic mucosal wound closure

Show the 1 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:81498
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA portion of exon 2 and all of exons 3 and 4 were replaced with a cassette containing lacZ and PGK-neo. Endogenous protein was undetected in homozygous mutant mice. lacZ expression was detected in various tissues. (J:81498)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 14 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Anxa1 Mutation:  2 strains or lines available
Original:  J:81498 Hannon R, et al., Aberrant inflammation and resistance to glucocorticoids in annexin 1-/- mouse. FASEB J. 2003 Feb;17(2):253-5
All:  54 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory