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Ctsatm1Adz
Targeted Allele Detail
Nomenclature
Symbol: Ctsatm1Adz
Name: cathepsin A; targeted mutation 1, Alessandro dAzzo
MGI ID: MGI:2449708
Synonyms: PPCA-, PPCA(-)
Gene: Ctsa  Location: Chr2:164832873-164841032 bp, + strand  Genetic Position: Chr2, 85.27 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:29674
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsExon 2 was disrupted with a hygromycin selection cassette inserted by homologous recombination. Transcript was undetected by Northern blot analysis of homozygous mutant mice. (J:29674)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 5 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ctsa Mutation:  21 strains or lines available
References
Original:  J:29674 Zhou XY, et al., Mouse model for the lysosomal disorder galactosialidosis and correction of the phenotype with overexpressing erythroid precursor cells. Genes Dev. 1995 Nov 1;9(21):2623-34
All:  7 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/11/2018
MGI 6.12
The Jackson Laboratory