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Slc1a2tm1Kta
Targeted Allele Detail
Nomenclature
Symbol: Slc1a2tm1Kta
Name: solute carrier family 1 (glial high affinity glutamate transporter), member 2; targeted mutation 1, Kohichi Tanaka
MGI ID: MGI:2449707
Synonyms: EAAT2 KO, GLT-1-
Gene: Slc1a2  Location: Chr2:102658659-102790784 bp, + strand  Genetic Position: Chr2, 54.13 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:40984
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsThe exon encoding the putative third transmembrane domain was disrupted by the insertion of a neomycin selection cassette. While transcript of approximately normal length was detected by Northern blot analysis of homozygous mutant cerebral RNA, RT-PCR analysis showed the transcript to lack exon 4. An absence of normal transcript was confirmed by in situ hybridization. Protein was undetected by Western blot analysis of cerebral membrane fractions. (J:40984)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Slc1a2 Mutation:  1 strain or line available
References
Original:  J:40984 Tanaka K, et al., Epilepsy and exacerbation of brain injury in mice lacking the glutamate transporter GLT-1. Science. 1997 Jun 13;276(5319):1699-702
All:  31 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/18/2020
MGI 6.14
The Jackson Laboratory