About   Help   FAQ
Targeted Allele Detail
Symbol: Unc13btm1Rmnd
Name: unc-13 homolog B (C. elegans); targeted mutation 1, Christian Rosenmund
MGI ID: MGI:2449706
Synonyms: Munc13-2 KO, Unc13bKO
Gene: Unc13b  Location: Chr4:43058953-43264871 bp, + strand  Genetic Position: Chr4, 23.0 cM, cytoband B1
Germline Transmission:  Earliest citation of germline transmission: J:77339
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsThe gene was disrupted by replacement of nucleotides 1439-2436 with a neomycin resistance gene via homologous recombination. Gene expression was completely absent in homozygous mutant animals as determined by Western blot analysis. An antibody recognizing all proteins isoforms was used for Western blotting. (J:77339)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Unc13b Mutation:  36 strains or lines available
Original:  J:77339 Varoqueaux F, et al., Total arrest of spontaneous and evoked synaptic transmission but normal synaptogenesis in the absence of Munc13-mediated vesicle priming. Proc Natl Acad Sci U S A. 2002 Jun 25;99(13):9037-42
All:  20 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
MGI 6.10
The Jackson Laboratory