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Unc13btm1Rmnd
Targeted Allele Detail
Nomenclature
Symbol: Unc13btm1Rmnd
Name: unc-13 homolog B (C. elegans); targeted mutation 1, Christian Rosenmund
MGI ID: MGI:2449706
Synonyms: Munc13-2 KO
Gene: Unc13b  Location: Chr4:43058953-43264871 bp, + strand  Genetic Position: Chr4, 23.0 cM, cytoband B1
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:77339
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe gene was disrupted by replacement of nucleotides 1439-2436 with a neomycin resistance gene via homologous recombination. Gene expression was completely absent in homozygous mutant animals as determined by Western blot analysis. An antibody recognizing all proteins isoforms was used for Western blotting. (J:77339)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Unc13b Mutation:  34 strains or lines available
References
Original:  J:77339 Varoqueaux F, et al., Total arrest of spontaneous and evoked synaptic transmission but normal synaptogenesis in the absence of Munc13-mediated vesicle priming. Proc Natl Acad Sci U S A. 2002 Jun 25;99(13):9037-42
All:  17 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory