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Lefty1tm1Sla
Targeted Allele Detail
Nomenclature
Symbol: Lefty1tm1Sla
Name: left right determination factor 1; targeted mutation 1, Siew-Lan Ang
MGI ID: MGI:2449694
Synonyms: Lefty1EIV
Gene: Lefty1  Location: Chr1:180935022-180938400 bp, + strand  Genetic Position: Chr1, 84.46 cM, cytoband F
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:81339
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Disruption caused by insertion of vector
    Exon 4, which encodes the mature protein (aa 249-368), was disrupted by homologous recombination. (J:81339)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Lefty1 Mutation:  4 strains or lines available
References
Original:  J:81339 Perea-Gomez A, et al., Nodal antagonists in the anterior visceral endoderm prevent the formation of multiple primitive streaks. Dev Cell. 2002 Nov;3(5):745-56
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
07/29/2020
MGI 6.15
The Jackson Laboratory