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Unc13ctm1Bros
Targeted Allele Detail
Nomenclature
Symbol: Unc13ctm1Bros
Name: unc-13 homolog C (C. elegans); targeted mutation 1, Nils Brose
MGI ID: MGI:2449467
Synonyms: Munc13-3-deficient, Unc13cKO
Gene: Unc13c  Location: Chr9:73479422-73968966 bp, - strand  Genetic Position: Chr9, 40.8 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:66984
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe gene was disrupted by the replacement of 2 exons encoding amino acids 1014-1066 with a neomycin resistance cassette via homologous recombination. Western blot analysis of brain proteins from homozygous mutant animals confirmed the null allele. (J:66984)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Unc13c Mutation:  54 strains or lines available
References
Original:  J:66984 Augustin I, et al., The cerebellum-specific Munc13 isoform Munc13-3 regulates cerebellar synaptic transmission and motor learning in mice. J Neurosci. 2001 Jan 1;21(1):10-7
All:  7 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/12/2017
MGI 6.10
The Jackson Laboratory