Ercc8^tm1Jhjh
Targeted Allele Detail

Summary

• Symbol: Ercc8^tm1Jhjh
• Name: excision repaiross-complementing rodent repair deficiency, complementation group 8; targeted mutation 1, Jan H J Hoeijmakers
• MGI ID: MGI:2449180
• Synonyms: Csa^-
• Gene: Ercc8 Location: Chr13:108295265-108331898 bp, + strand Genetic Position: Chr13, 59.69 cM, cytoband D
• Alliance: Ercc8^tm1Jhjh page

Microglia activation in the white matter in Ercc2, Ercc6, and Ercc8 mutants

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:74959
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: The gene was disrupted by insertion of a PGK-hygro cassette into exon 2 (at amino acid 42) via homologous recombination. Absence of gene expression was verified by Western blot analysis of homozygous mutant MEFs using an antibody directed against the C-terminal domain of the human protein. (J:74959)

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Ercc8^tm1Jhjh

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ercc8 Mutation: 31 strains or lines available

References

• Original: J:74959 van der Horst GT, et al., UVB radiation-induced cancer predisposition in Cockayne syndrome group A (Csa) mutant mice. DNA Repair (Amst). 2002;1:143-57
• All: 9 reference(s)