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Targeted Allele Detail
Symbol: Nfiatm1Rmg
Name: nuclear factor I/A; targeted mutation 1, Richard M Gronostajski
MGI ID: MGI:2449024
Synonyms: Nfia-
Gene: Nfia  Location: Chr4:97772734-98118871 bp, + strand  Genetic Position: Chr4, 45.52 cM, cytoband C4-C6
Hydrocephalus in Nfiatm1Rmg/Nfiatm1Rmg mice

Show the 8 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:58137
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsThe gene was disrupted by replacement of 219 bp of exon 2 and the 3' splice acceptor with a PGK-neo cassette via homologous recombination. The mutant allele generates a fusion between exons 1 and 3 resulting in an out-of-frame transcript with a nonsense codon in exon 3. The mutant allele was verified by RT-PCR and sequence analysis. (J:58137)
View phenotypes for all genotypes (concatenated display).
In Mice Carrying this Mutation: 2 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Nfia Mutation:  7 strains or lines available
Original:  J:58137 das Neves L, et al., Disruption of the murine nuclear factor I-A gene (Nfia) results in perinatal lethality, hydrocephalus, and agenesis of the corpus callosum. Proc Natl Acad Sci U S A. 1999 Oct 12;96(21):11946-51
All:  13 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.06
The Jackson Laboratory