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Transgenic Allele Detail
Symbol: Grm7Tg(SMN2)89Ahmb
Name: glutamate receptor, metabotropic 7; transgene insertion 89, Arthur H M Burghes
MGI ID: MGI:2448989
Synonyms: SMN2
Gene: Grm7  Location: Chr6:110645581-111567230 bp, + strand  Genetic Position: Chr6, 51.19 cM
Strain of Origin:  FVB/N
Transgene Type:    Transgenic (Humanized sequence, Hypomorph, Inserted expressed sequence)
Mutation:    Insertion
Grm7Tg(SMN2)89Ahmb expresses 1 gene
Mutation detailsA 35.5 kb genomic fragment containing the human survival motor neuron 2 (SMN2) gene and promoter was used for the transgene. The transgene is ubiquitously expressed in all tissues examined by Northern blot analysis. Line 89 carries 1 copy of the transgene integrated into intron 4 of the gene. RT-PCR confirmed reduced expression of the gene the transgene is integrated into. (J:60592, J:174332)
View phenotypes for all genotypes (concatenated display).
Disease models
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 28 strains available      Cell Lines: 0 lines available
Carrying any Grm7 Mutation:  72 strains or lines available
Original:  J:60592 Monani UR, et al., The human centromeric survival motor neuron gene (SMN2) rescues embryonic lethality in Smn(-/-) mice and results in a mouse with spinal muscular atrophy. Hum Mol Genet. 2000 Feb 12;9(3):333-9
All:  88 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.06
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