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Targeted Allele Detail
Symbol: Nkx2-5tm2(cre)Rph
Name: NK2 homeobox 5; targeted mutation 2, Richard P Harvey
MGI ID: MGI:2448972
Synonyms: Nkx2.5-Cre, Nkx2-5IRESCre
Gene: Nkx2-5  Location: Chr17:26838664-26844995 bp, - strand  Genetic Position: Chr17, 13.6 cM
Germline Transmission:  Earliest citation of germline transmission: J:80725
Parent Cell Line:  W9.5/W95 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Allele Type:    Targeted (No functional change, Recombinase)
Mutation:    Insertion
Mutation detailsSequence encoding cre recombinase adjoined to an IRES was inserted into the 3' UTR of the endogenous locus via homologous recombination. A single frt site remained in the UTR after an frt-flanked hygromycin selection cassette was excised. A lack of observed allele complementation indicated that the inserted sequence did not significantly affect expression of the endogenous locus. (J:80725)
Generation of the Smyd2tm1.1Fben allele
 Tissue activity of this recombinase allele
Driver: Nkx2-5     Summary of all recombinase alleles driven by Nkx2-5. Comparative matrix view of recombinase activities

View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 40 assay results
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Nkx2-5 Mutation:  14 strains or lines available
Original:  J:80725 Stanley EG, et al., Efficient Cre-mediated deletion in cardiac progenitor cells conferred by a 3'UTR-ires-Cre allele of the homeobox gene Nkx2-5. Int J Dev Biol. 2002;46(4):431-9
All:  42 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory