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Nrtntm1Jmi
Targeted Allele Detail
Nomenclature
Symbol: Nrtntm1Jmi
Name: neurturin; targeted mutation 1, Jeffrey Milbrandt
MGI ID: MGI:2448936
Synonyms: Nrtn-, NTN-
Gene: Nrtn  Location: Chr17:56751325-56757530 bp, - strand  Genetic Position: Chr17, 29.49 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:53261
Parent Cell Line:  RW-4 (ES Cell)
Strain of Origin:  129X1/SvJ
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe gene was disrupted by replacement of the entire coding region with a neomycin resistance cassette via homologous recombination. Absence of gene expression in homozygous mutant animals was confirmed by RT-PCR analysis of heart mRNA. (J:53261)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Nrtn Mutation:  3 strains or lines available
References
Original:  J:53261 Heuckeroth RO, et al., Gene targeting reveals a critical role for neurturin in the development and maintenance of enteric, sensory, and parasympathetic neurons [see comments]. Neuron. 1999 Feb;22(2):253-63
All:  14 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory