About   Help   FAQ
Nrtntm1Jmi
Targeted Allele Detail
Nomenclature
Symbol: Nrtntm1Jmi
Name: neurturin; targeted mutation 1, Jeffrey Milbrandt
MGI ID: MGI:2448936
Synonyms: Nrtn-, NTN-
Gene: Nrtn  Location: Chr17:56751325-56757530 bp, - strand  Genetic Position: Chr17, 29.49 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:53261
Parent Cell Line:  RW-4 (ES Cell)
Strain of Origin:  129X1/SvJ
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe gene was disrupted by replacement of the entire coding region with a neomycin resistance cassette via homologous recombination. Absence of gene expression in homozygous mutant animals was confirmed by RT-PCR analysis of heart mRNA. (J:53261)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Nrtn Mutation:  5 strains or lines available
References
Original:  J:53261 Heuckeroth RO, et al., Gene targeting reveals a critical role for neurturin in the development and maintenance of enteric, sensory, and parasympathetic neurons [see comments]. Neuron. 1999 Feb;22(2):253-63
All:  14 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
09/12/2017
MGI 6.10
The Jackson Laboratory