Tg(CD2-MYC)1Jcn
Transgene Detail

Summary

• Symbol: Tg(CD2-MYC)1Jcn
• Name: transgene insertion 1, J C Neil
• MGI ID: MGI:2448760
• Synonyms: CD2-MYC
• Transgene: Tg(CD2-MYC)1Jcn Location: unknown
• Alliance: Tg(CD2-MYC)1Jcn page

Transgene origin

• Strain of Origin: (C57BL/6J x CBA/Ca)F2

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(CD2-MYC)1Jcn expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  MYC (4609)

  Myc	(MGI:97250)

• Mutation details: The transgene consists of a human MYC genomic sequence and a 5.5 kb fragment containing the human CD2 dominant control region to drive expression in T lymphocytes. Northern blot analysis using a human MYC exon 1 probe revealed transgene expression in all thymic tumors, but not in healthy tissues. (J:81276)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

Notes

Two transgenic lines designated the 800 series and 900 series was established. Animals of the 800 series carry 13 copies of the integrated transgene and exhibit 22% incidence of thymic lymphomas. Animals of the 900 series carry 3 copies of the integrated transgene and exhibit 3% incidence of thymic lymphomas.

References

• Original: J:81276 Stewart M, et al., Conditional expression and oncogenicity of c-myc linked to a CD2 gene dominant control region. Int J Cancer. 1993 Apr 1;53(6):1023-30
• All: 6 reference(s)