Tg(CD2-MYC/Esr1)1Guvf
Transgene Detail

Summary

• Symbol: Tg(CD2-MYC/Esr1)1Guvf
• Name: transgene insertion 1, Glasgow University Veterinary Faculty
• MGI ID: MGI:2448752
• Synonyms: CD2-mycER^TM
• Transgene: Tg(CD2-MYC/Esr1)1Guvf Location: unknown
• Alliance: Tg(CD2-MYC/Esr1)1Guvf page

Transgene origin

• Strain of Origin: (C57BL/6 x CBA/Ca)F2

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(CD2-MYC/Esr1)1Guvf expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  MYC (4609)

  Bmyc	(MGI:88184)
  Myc	(MGI:97250)

• Mutation details: The transgene consists of a human MYC sequence fused to a tamoxifen-inducible mouse Esr1 sequence, and a human CD2 promoter, which drives expression in T lymphocytes. (J:60583)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:60583 Blyth K, et al., Sensitivity to myc-induced apoptosis is retained in spontaneous and transplanted lymphomas of CD2-mycER mice. Oncogene. 2000 Feb 10;19(6):773-82
• All: 3 reference(s)