Tg(S100A8-BCL2)1Lgs
Transgene Detail

Summary

• Symbol: Tg(S100A8-BCL2)1Lgs
• Name: transgene insertion 1, Eric Lagasse
• MGI ID: MGI:2448741
• Synonyms: hMRP8C-MYC, MRP8BCL-2
• Transgene: Tg(S100A8-BCL2)1Lgs Location: unknown
• Alliance: Tg(S100A8-BCL2)1Lgs page

Transgene origin

• Strain of Origin: (C3H x C57BL/6)F1

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(S100A8-BCL2)1Lgs expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  BCL2 (596)

  Bcl2	(MGI:88138)

• Mutation details: A human BCL2 cDNA directed by human S100A8 regulatory sequences, including the promoter, exon 1, and exon 2, were used for the transgene. Transgene expression was observed by immunohistochemistry in bone marrow and spleen from transgenic animals. (J:81148)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available

References

• Original: J:81148 Lagasse E, et al., bcl-2 inhibits apoptosis of neutrophils but not their engulfment by macrophages. J Exp Med. 1994 Mar 1;179(3):1047-52
• All: 10 reference(s)