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Prkaa2tm1.1Vio
Targeted Allele Detail
Nomenclature
Symbol: Prkaa2tm1.1Vio
Name: protein kinase, AMP-activated, alpha 2 catalytic subunit; targeted mutation 1.1, Benoit Viollet
MGI ID: MGI:2448467
Synonyms: alpha2 AMPK KO, alpha2KO, AMPK-, Ampka2-, AMPKalpha2-
Gene: Prkaa2  Location: Chr4:105029874-105109890 bp, - strand  Genetic Position: Chr4, 49.05 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:81120
Parent Cell Line:  Other (see notes) (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe floxed region containing the exon encoding amino acids 189 through 260 and a downstream neo cassette was excised from Prkaa2tm1Vio in the germline via in vivo cre-mediated recombination. Protein was undetected by Western blot analysis of liver and muscle tissue obtained from homozygous mutant mice. (J:81120)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 4 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Prkaa2 Mutation:  8 strains or lines available
Notes
ES cell line = MPI-I (MPI1).
References
Original:  J:81120 Viollet B, et al., The AMP-activated protein kinase alpha2 catalytic subunit controls whole-body insulin sensitivity. J Clin Invest. 2003 Jan;111(1):91-8
All:  94 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
06/23/2020
MGI 6.15
The Jackson Laboratory