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Prkaa2tm1.1Vio
Targeted Allele Detail
Summary
Symbol: Prkaa2tm1.1Vio
Name: protein kinase, AMP-activated, alpha 2 catalytic subunit; targeted mutation 1.1, Benoit Viollet
MGI ID: MGI:2448467
Synonyms: alpha2 AMPK KO, alpha2KO, AMPK-, Ampka2-, AMPKalpha2-
Gene: Prkaa2  Location: Chr4:104887071-104967087 bp, - strand  Genetic Position: Chr4, 49.05 cM
Alliance: Prkaa2tm1.1Vio page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:81120
Parent Cell Line:  Other (see notes) (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe floxed region containing the exon encoding amino acids 189 through 260 and a downstream neo cassette was excised from Prkaa2tm1Vio in the germline via in vivo cre-mediated recombination. Protein was undetected by Western blot analysis of liver and muscle tissue obtained from homozygous mutant mice. (J:81120)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation: 5 anatomical structure(s)
Tumor Data
List all tumor models in MMHCdb carrying Prkaa2tm1.1Vio
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Prkaa2 Mutation:  33 strains or lines available
Notes
ES cell line = MPI-I (MPI1).
References
Original:  J:81120 Viollet B, et al., The AMP-activated protein kinase alpha2 catalytic subunit controls whole-body insulin sensitivity. J Clin Invest. 2003 Jan;111(1):91-8
All:  107 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory