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Targeted Allele Detail
Symbol: Igfbp1tm1Taub
Name: insulin-like growth factor binding protein 1; targeted mutation 1, Rebecca Taub
MGI ID: MGI:2448461
Synonyms: IGFBP-1-
Gene: Igfbp1  Location: Chr11:7197787-7202546 bp, + strand  Genetic Position: Chr11, 4.75 cM
Germline Transmission:  Earliest citation of germline transmission: J:81123
Parent Cell Line:  RW-4 (ES Cell)
Strain of Origin:  129X1/SvJ
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA sequence fragmenet encompassing 234 bp of the promoter and exons 1 and 2 was replaced with a PGK-neo cassette inserted by homologous recombination. Endogenous transcript was undetected by Northern blot analysis of homozygous mutant mice following partial hepatectomy. Western blot analysis of whole liver extracts from quiescent and 1 to 8 hour posthepatectomy homozygous mutant mice showed an absence of normal protein. (J:81817)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Igfbp1 Mutation:  12 strains or lines available
Original:  J:81123 Leu JI, et al., Massive hepatic apoptosis associated with TGF-beta1 activation after Fas ligand treatment of IGF binding protein-1-deficient mice. J Clin Invest. 2003 Jan;111(1):129-39
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.16
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