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Syn1tm1Pggd
Targeted Allele Detail
Summary
Symbol: Syn1tm1Pggd
Name: synapsin I; targeted mutation 1, Paul Greengard
MGI ID: MGI:2448356
Synonyms: Syn1tm1Lli, SynI-
Gene: Syn1  Location: ChrX:20726750-20787157 bp, - strand  Genetic Position: ChrX, 16.37 cM, cytoband A1-A4
Alliance: Syn1tm1Pggd page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:29085
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExon 1 was replaced by a neomycin selection cassette inserted by homologous recombination. Western blot analysis of homozygous mutant brain tissues indicated an absence of both protein isoforms, Synapsin Ia and Synapsin Ib, produced by the endogenous locus. (J:29085)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 2 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Syn1 Mutation:  22 strains or lines available
References
Original:  J:29085 Chin LS, et al., Impairment of axonal development and of synaptogenesis in hippocampal neurons of synapsin I-deficient mice. Proc Natl Acad Sci U S A. 1995 Sep 26;92(20):9230-4
All:  44 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory