Tg(Alb1-TGFB1)1Sst
Transgene Detail

Summary

• Symbol: Tg(Alb1-TGFB1)1Sst
• Name: transgene insertion 1, Snorri S Thorgeirsson
• MGI ID: MGI:2448260
• Synonyms: Alb/TGF-beta1
• Transgene: Tg(Alb1-TGFB1)1Sst Location: unknown
• Alliance: Tg(Alb1-TGFB1)1Sst page

Transgene origin

• Strain of Origin: (C57BL/6J x CBA)F1

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Alb1-TGFB1)1Sst expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  pig, domestic	TGFB1 (397078)

• Mutation details: This hepatocyte-specific transgene consists of the mouse Alb1 enhancer and proximal promoter and 1.5 kb of a modified porcine TGFB1 cDNA. Cysteines 223 and 225 were substituted with serine residues. A 625 bp sequence of the human growth hormone gene 3' untranslated region and polyadenylation sequence was also added. Transgene expression in the liver of transgenic animals was confirmed by Northern blot analysis. Transgenic lines 2, 18, 34, and 25 express high levels of the transgene. (J:24154)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:24154 Sanderson N, et al., Hepatic expression of mature transforming growth factor beta 1 in transgenic mice results in multiple tissue lesions. Proc Natl Acad Sci U S A. 1995 Mar 28;92(7):2572-6
• All: 20 reference(s)