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Targeted Allele Detail
Symbol: Zyxtm1Mbk
Name: zyxin; targeted mutation 1, Mary C Beckerle
MGI ID: MGI:2448217
Synonyms: zyxin-
Gene: Zyx  Location: Chr6:42349630-42360213 bp, + strand  Genetic Position: Chr6, 20.64 cM
Germline Transmission:  Earliest citation of germline transmission: J:81007
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129X1/SvJ
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsThe gene was disrupted by replacement of a 4.5 kb region of the gene containing a 5' non-coding exon and the first 4 exons encoding amino acids 1-333. Absence of gene expression was confirmed by Western blot analysis of lung and spleen mRNA from homozygous mutant animals. Multiple antibodies directed against N-terminal, central, and C-terminal residues did not detect any protein product. (J:81007)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Zyx Mutation:  13 strains or lines available
The authors report the 129SvJ GS embryonic stem cell line (Genome Systems, Inc., St.Louis, MO) was used for gene targeting.
Original:  J:81007 Hoffman LM, et al., Targeted disruption of the murine zyxin gene. Mol Cell Biol. 2003 Jan;23(1):70-9
All:  3 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
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