About   Help   FAQ
Zyxtm1Mbk
Targeted Allele Detail
Nomenclature
Symbol: Zyxtm1Mbk
Name: zyxin; targeted mutation 1, Mary C Beckerle
MGI ID: MGI:2448217
Synonyms: zyxin-
Gene: Zyx  Location: Chr6:42349630-42360213 bp, + strand  Genetic Position: Chr6, 20.64 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:81007
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129X1/SvJ
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe gene was disrupted by replacement of a 4.5 kb region of the gene containing a 5' non-coding exon and the first 4 exons encoding amino acids 1-333. Absence of gene expression was confirmed by Western blot analysis of lung and spleen mRNA from homozygous mutant animals. Multiple antibodies directed against N-terminal, central, and C-terminal residues did not detect any protein product. (J:81007)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Zyx Mutation:  13 strains or lines available
Notes
The authors report the 129SvJ GS embryonic stem cell line (Genome Systems, Inc., St.Louis, MO) was used for gene targeting.
References
Original:  J:81007 Hoffman LM, et al., Targeted disruption of the murine zyxin gene. Mol Cell Biol. 2003 Jan;23(1):70-9
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
11/28/2017
MGI 6.11
The Jackson Laboratory