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Targeted Allele Detail
Symbol: Ccr3tm1Cge
Name: chemokine (C-C motif) receptor 3; targeted mutation 1, Craig Gerard
MGI ID: MGI:2448180
Synonyms: CCR3-, CCR3 KO
Gene: Ccr3  Location: Chr9:123822009-123831726 bp, + strand  Genetic Position: Chr9, 75.05 cM, cytoband F
Germline Transmission:  Earliest citation of germline transmission: J:74509
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsThe gene was disrupted by replacement of a 3 kb region containing the start codon, 39 bp of the N-terminal coding region, and the 5' untranslated region with a PGK-neo cassette via homologous recombination. Absence of gene expression was confirmed by RT-PCR analysis of bone marrow mRNA from homozygous mutant animals. (J:74509)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ccr3 Mutation:  19 strains or lines available
Original:  J:74509 Humbles AA, et al., The murine CCR3 receptor regulates both the role of eosinophils and mast cells in allergen-induced airway inflammation and hyperresponsiveness. Proc Natl Acad Sci U S A. 2002 Feb 5;99(3):1479-84
All:  24 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.17
The Jackson Laboratory