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Ccr3tm1Cge
Targeted Allele Detail
Nomenclature
Symbol: Ccr3tm1Cge
Name: chemokine (C-C motif) receptor 3; targeted mutation 1, Craig Gerard
MGI ID: MGI:2448180
Synonyms: CCR3-, CCR3 KO
Gene: Ccr3  Location: Chr9:124021971-124031689 bp, + strand  Genetic Position: Chr9, 75.05 cM, cytoband F
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:74509
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe gene was disrupted by replacement of a 3 kb region containing the start codon, 39 bp of the N-terminal coding region, and the 5' untranslated region with a PGK-neo cassette via homologous recombination. Absence of gene expression was confirmed by RT-PCR analysis of bone marrow mRNA from homozygous mutant animals. (J:74509)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ccr3 Mutation:  8 strains or lines available
References
Original:  J:74509 Humbles AA, et al., The murine CCR3 receptor regulates both the role of eosinophils and mast cells in allergen-induced airway inflammation and hyperresponsiveness. Proc Natl Acad Sci U S A. 2002 Feb 5;99(3):1479-84
All:  18 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory