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Nr6a1tm2Coo
Targeted Allele Detail
Nomenclature
Symbol: Nr6a1tm2Coo
Name: nuclear receptor subfamily 6, group A, member 1; targeted mutation 2, Austin J Cooney
MGI ID: MGI:2448158
Synonyms: GCNFlox
Gene: Nr6a1  Location: Chr2:38723370-38927688 bp, - strand  Genetic Position: Chr2, 24.42 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:80978
Parent Cell Line:  AB1 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprt+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsThe 243 bp exon encoding the DNA-binding domain was replaced by a single loxP site after cre mediated recombination within ES cells. A truncated protein, lacking the DNA-binding domain but retaining the downstream ligand-binding domain was detected by Western blot analysis of homozygous mutant mice. (J:80978)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Nr6a1 Mutation:  126 strains or lines available
References
Original:  J:80978 Lan ZJ, et al., The embryonic function of germ cell nuclear factor is dependent on the DNA binding domain. J Biol Chem. 2002 Dec 27;277(52):50660-7
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory